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- BACTRIM DS Sulfamethoxazole,Trimethoprim dosage, indication.
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Bactrim Ds (generic name: Co-trimoxazole; brand names include: Septra / Ciplin / Septrin) is a combination of two antibiotics (trimethoprim and sulfamethoxazole) used to treat a wide variety of bacterial infections.
BACTRIM DS Sulfamethoxazole,Trimethoprim dosage, indication.
To reduce the development of drug-resistant bacteria and maintain the effectiveness of Bactrim (sulfamethoxazole and trimethoprim) tablets and other antibacterial drugs, Bactrim (sulfamethoxazole and trimethoprim) tablets should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.
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UTIs caused by susceptible strains of Escherichia coli, Klebsiella species, Enterobacter species, Morganella morganii, Proteus mirabilis, and Proteus vulgaris Pyelonephritis: 1 DS tab or 2 regular-strength tabs PO q12hr x 14 days Prostatitis: 1 DS tab or 2 regular-strength tabs PO q12hr x 14 days or 2-3 months if chronic infection A 3 to 5 day course may be used for acute, uncomplicated cystitis Prophylaxis (off-label): Various regimens exist; may use regular-strength tablet once/twice per week Anorexia Nausea Vomiting Verto Seizure Peripheral neuritis Erythema multiforme Hyperkalemia Rash Urticaria Immune hypersensitivity reaction Stevens-Johnson syndrome Toxic epidermal necrolysis Agranulocytosis Aplastic anemia Hyponatremia Disorder of hematopoietic structure Fulminant hepatic necrosis 10% Trimethoprim decreases urinary potassium excretion; may cause hyperkalemia, particularly with hh doses, renal insufficiency, or when combined with other drugs that cause hyperkalemia Severe and symptomatic hyponatremia reported with hh dose trimethoprim Rare fatalities reported with sulfonamides due to Stevens-Johnson syndrome, toxic epidermal necrolysis, fulminant hepatic necrosis, agranulocytosis, aplastic anemia, and other blood dyscrasias Caution when used in elderly individuals; risk of bone marrow suppression PCP prophylaxis with AIDS: Rash, fever, leukopenia, and elevated transaminase values reported; hyperkalemia and hyponatremia also appear to be increased Severe cases (including fatalities) of immune-mediated thrombocytopenia reported Sulfonamides should not be used to treat A beta-hemolytic streptococcal infections; they will not eradicate streptococcus or prevent rheumatic fever Clostridium difficile-associated diarrhea reported Coadministration with leucovorin for the treatment of HIV-positive patients with PCP resulted in treatment failure and excess mortality in a randomized, placebo-controlled trial; avoid coadministration Development of drug-resistant bacteria may occur when prescribed in absence of strongly suspected bacterial infection or prophylactic indication Prolonged use may result in fungal or bacterial superinfection Caution with impaired renal or hepatic function, patients with possible folate deficiency (eg, the elderly, chronic alcoholics, patients receiving anticonvulsant therapy, patients with malabsorption syndrome, and patients in malnutrition states), and patients with severe allergies or bronchial asthma Hemolysis may occur if administered to patients with G6PD deficiency Hypoglycemia (rare) reported in nondiabetic patients; patients with renal dysfunction, liver disease, or malnutrition or those receiving hh doses at particular risk Trimethoprim may impair phenylalanine metabolism Caution with porphyria or thyroid dysfunction Pregnancy category: D; avoid near term due to risk of kernicterus in the newborn (see Contraindications) Some epidemiologic studies suggest that exposure to sulfamethoxazole/trimethoprim during pregnancy may be associated with an increased risk of congenital malformations, particularly neural tube defects, cardiovascular malformations, urinary tract defects, oral clefts, and club foot Lactation: Excreted in breast milk; use caution; contraindicated by some sources (AAP Committee states compatible with nursing) Blocks 2 consecutive steps in the biosynthesis of nucleic acids and proteins essential to many bacteria Trimethoprim: Inhibits dihydrofolate reductase, thereby blocking production of tetrahydrofolic acid from dihydrofolic acid Sulfamethoxazole: Inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid Additive: Fluconazole, linezolid, verapamil Y-site: Cisatracurium (incompatible at 2 mg/m L cisatra; may be compatible at much lower concs), fluconazole, foscarnet (may be compatible at very low TMP/SMX concs), midazolam, vinorelbine The above information is provided for general informational and educational purposes only.
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